01 / UNDERSTANDING WGS
The genome is broad.
The interpretation is focused.
WGS examines both protein-coding and noncoding DNA. It produces more information than a test limited to a few selected variants, but sequencing breadth and clinical reporting are different things. Not every genetic difference has an established meaning for your health.
OmniWell’s planned WGS pathway combines clinical laboratory testing with physician interpretation. We confirm the report scope before ordering and interpret the findings alongside your medical history, family history, examination, and other assessments.
02 / INSIDE THE REPORT
Several perspectives.
One clinical review.
The whole-genome sequencing test and clinical report bring the following categories together. These are components of one WGS report, rather than separate test orders.
- Hereditary Disease Risk
- Selected reportable variants associated with inherited conditions, including cancer predisposition and cardiovascular disease. Examples in the planned reporting scope include BRCA1/BRCA2, LDLR, and LMNA. A finding may prompt a more focused evaluation or a discussion about screening.
- Carrier-Status Findings
- Selected inherited variants that may matter for relatives, family planning, or genetic counseling, even when the person carrying the variant is healthy.
- Medication Response
- Pharmacogenomics examines selected gene–medication relationships. Findings may help inform a prescribing decision when a relevant medication is being considered; they do not replace your prescriber’s assessment.
- Polygenic Risk
- Estimates for selected common diseases based on multiple genetic variants. These scores add context to risk assessment. Your ancestry, the model’s applicability, and clinical factors remain important to interpretation.
- Nutrition & Wellness Traits
- Genetic context for discussions about nutrition, food response, and exercise. Your actual diet, laboratory results, body composition, and physical performance help determine which findings are useful.
03 / FROM FINDINGS TO CARE
Information becomes useful
when it informs a decision.
A report is the starting point for a conversation. Your physician helps distinguish findings that may change care from those that provide background context.
Put the finding in context.
Review the result alongside your history, symptoms, family patterns, and measured health. A genetic association alone does not establish a need for treatment.
Identify the next appropriate step.
Depending on the finding, that may mean a medication discussion, a review of screening recommendations, confirmatory testing, or a referral for genetic counseling or specialist assessment.
Connect it to your personal plan.
Discuss what changes, what stays the same, and what needs follow-up. Your plan reflects the complete clinical picture rather than a genetic result in isolation.
04 / WHAT TO EXPECT
A considered process,
before and after the test.
Before Testing
Bring your medication list, relevant family history, and any previous genetic reports. Discuss which findings may be returned, their possible implications for relatives, and the laboratory’s consent and data-use choices.
Sample Collection
We confirm collection and preparation instructions before testing. The planned testing pathway uses a blood sample. Collection arrangements and the expected reporting timeframe are confirmed when ordering.
Results Review
Your physician explains the clinical report and discusses any appropriate follow-up. Additional testing beyond the report or outside genetic counseling is separately quoted.
Testing Frequency
OmniWell currently lists WGS at the initial assessment in Signature and Pinnacle, with physician interpretation. Existing findings may be reviewed when useful; there is no automatic annual resequencing or repeat kit.
View the Full WGS Assessment Listing →05 / UNDERSTANDING THE LIMITS
Useful insight.
Clear boundaries.
- Risk is not certainty. A finding associated with increased risk does not mean that a disease will occur. A negative report cannot rule out every inherited risk.
- Not every change is detected or reported. Some regions and types of genetic variation are difficult to assess. The planned healthy-screening report excludes variants of uncertain significance and reports qualifying pathogenic or likely pathogenic hereditary findings.
- Screening and diagnosis serve different purposes. This pathway is a health-risk screen. Symptoms or a suspected inherited disorder may require a different diagnostic test or specialist evaluation.
- Context still matters. Testing does not replace appropriate screening, family-history assessment, or ongoing clinical care. Genetic findings may also have emotional and family implications worth discussing before testing.
More about the benefits and limitations of genetic testing ↗
06 / COMMON QUESTIONS
A few useful distinctions.
Is WGS the same as biological-age testing?
No. WGS examines your DNA sequence. DNA methylation tests examine chemical marks on DNA and use models to estimate aspects of biological aging. WGS does not provide a TruAge or pace-of-aging result.
Explore DNA Methylation & Epigenetic Age →Will my results affect my family?
Some findings can be relevant to relatives or future children. Your physician can discuss whether genetic counseling or a family member’s evaluation would be appropriate. Family implications are part of the conversation before testing.
Should I change medication or supplements based on a result?
Review the result with your prescribing clinician before making a change. Medication response, nutrition traits, laboratory measurements, and your medical history need to be considered together.
Can the interpretation change over time?
Yes. Evidence and reporting scope can evolve. Reanalysis of existing sequence data is different from collecting a new sample and sequencing again. Availability and any additional costs are confirmed before arranging reanalysis.
07 / SOURCES & FURTHER READING
Explore the science
behind the assessment.
This guide provides general educational information. Test selection and interpretation are individualized.