.genomics-reference{--reference-blue:#15394e;--reference-line:#c1d1dc;background:#f3f6f7;color:#152d3d}
.reference-hero{padding:32px 0 48px;background:linear-gradient(115deg,#e8f1f6,#d7e7f0)}
.reference-hero .detail-breadcrumbs{margin-bottom:34px}
.reference-hero h1{font-size:clamp(2.5rem,4.9vw,4.5rem);line-height:1.07;letter-spacing:-.045em;font-weight:350;max-width:1000px;text-wrap:balance}
.reference-hero .eyebrow{color:#315366;font-size:1rem;letter-spacing:1px;margin-bottom:20px}
.reference-intro{font-size:1.25rem;line-height:1.75;max-width:850px;margin-top:24px;color:#304d60}
.reference-meta{display:flex;flex-wrap:wrap;gap:12px 25px;font-size:1rem;color:#36576a;margin-top:28px}
.reference-meta span+span{border-left:1px solid #9db8c9;padding-left:25px}
.reference-nav{position:sticky;top:var(--header-height,100px);z-index:30;background:#dcebf3;border-top:1px solid #b4cddc;border-bottom:1px solid #b4cddc;box-shadow:0 4px 14px #0a28300a}
.reference-nav-links{display:flex;justify-content:space-between;gap:8px}
.reference-nav-links a{font-size:1rem;padding:19px 9px;min-height:60px;line-height:1.4;display:flex;align-items:center;border-bottom:3px solid transparent;color:#254c64}
.reference-nav-links a:hover,.reference-nav-links a[aria-current]{border-bottom-color:#224e69;color:#102f43;background:#cddfea}
.reference-nav-mobile{display:none;padding:10px 0}
.reference-nav-mobile label{font-size:1rem;font-weight:500}
.reference-nav-mobile select{min-height:46px;border:1px solid #8caaba;background:#f6fafc;color:#15394e;border-radius:3px;padding:8px 30px 8px 12px;font:inherit;width:100%;min-width:0}
.reference-body{padding-top:48px;padding-bottom:64px}
.reference-search{padding:28px 30px;background:#e6eef3;border:1px solid var(--reference-line);border-radius:4px;margin-bottom:40px}
.reference-search label{font-size:1.25rem;font-weight:450;display:block;margin-bottom:14px}
.reference-search-controls{display:flex;gap:12px;align-items:stretch}
.reference-search input{font:inherit;font-size:1.125rem;color:#152d3d;background:#fff;border:1px solid #7799ad;min-height:54px;padding:13px 16px;flex:1;min-width:0;border-radius:3px}
.reference-search input::placeholder{color:#526a78;opacity:1}
.reference-search button,.reference-clear{font:inherit;font-size:1rem;padding:12px 20px;min-height:48px;border:1px solid #547b93;background:#f8fbfd;color:#15394e;border-radius:3px;cursor:pointer}
.reference-search p{font-size:1rem;line-height:1.65;color:#36566b;margin-top:12px}
.reference-search [role=status]{color:#15394e;font-weight:450}
.reference-results{margin:-12px 0 48px;padding:28px 30px;background:#fff;border:1px solid #aac3d2;border-top:4px solid #547f9a;border-radius:4px;scroll-margin-top:calc(var(--reference-nav-height,70px) + 12px)}
.reference-results[hidden],.reference-results-empty[hidden],.reference-results-return[hidden]{display:none!important}
.reference-results-heading h2{font-size:1.75rem;line-height:1.3;font-weight:500;margin:0 0 8px;letter-spacing:-.02em}
.reference-results-heading p{font-size:1.125rem;line-height:1.6;color:#254c64;margin:0}
.reference-results-help{font-size:1rem;line-height:1.65;color:#36566b;margin:12px 0 24px;max-width:850px}
.reference-result-group+.reference-result-group{margin-top:28px}
.reference-result-group h3{font-size:1.0625rem;line-height:1.5;font-weight:500;color:#31566e;margin:0 0 12px}
.reference-result-list{list-style:none;padding:0;margin:0;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}
.reference-result-link{display:flex;flex-direction:column;height:100%;padding:18px 20px;background:#edf4f8;border:1px solid #c1d4df;border-radius:3px;text-decoration:none;color:#15394e;overflow-wrap:anywhere}
.reference-result-link:hover{background:#dfedf5;border-color:#769cb4}
.reference-result-link strong{font-size:1.125rem;line-height:1.4;font-weight:500}
.reference-result-detail{display:block;font-size:1rem;line-height:1.65;margin:8px 0 12px;color:#34576c}
.reference-result-action{display:block;margin-top:auto;font-size:1rem;line-height:1.5;color:#194f70;text-decoration:underline;text-underline-offset:3px}
.reference-result-more,.reference-results-return{display:inline-block;font-size:1rem;line-height:1.6;min-height:44px;padding:12px 0;color:#194f70;text-decoration:underline;text-underline-offset:4px}
.reference-result-more{margin-top:6px}
.reference-results-empty p{font-size:1.125rem;line-height:1.7;margin:0 0 16px;color:#34576c}
.reference-table tbody tr{scroll-margin-top:calc(var(--reference-nav-height,70px) + 12px)}
.reference-table tbody tr.reference-target{outline:2px solid #547f9a;outline-offset:2px}
.reference-table tbody tr.reference-target>*{background:#dcebf3}
.reference-scope{font-size:1.125rem;line-height:1.8;max-width:1000px;margin-bottom:44px;color:#304b5b}
.reference-scope strong{color:#17394d;font-weight:500}
.reference-section{padding:0 0 54px;margin:0 0 48px;border-bottom:1px solid var(--reference-line);scroll-margin-top:calc(var(--reference-nav-height,70px) - 4px)}
.reference-section>.eyebrow{font-size:1rem;letter-spacing:1px;color:#35596e;margin-bottom:14px}
.reference-section h2{font-size:clamp(1.9rem,3.25vw,2.8rem);font-weight:400;letter-spacing:-.03em;line-height:1.2;text-wrap:balance;margin-bottom:20px}
.reference-section h3{font-size:1.4rem;font-weight:450;line-height:1.4;margin-top:30px;margin-bottom:14px}
.reference-section>p,.reference-section li{font-size:1.125rem;line-height:1.8;color:#304b5b;max-width:1050px;margin-bottom:18px}
.reference-section a{color:#194f70;text-decoration:underline;text-underline-offset:4px}
.reference-section ul{padding-left:23px}
.reference-note{padding:22px 26px;background:#e2edf3;border-left:3px solid #537d96;margin:26px 0;font-size:1.0625rem;line-height:1.8;color:#25485e}
.reference-note p{margin:0 0 12px}.reference-note p:last-child{margin-bottom:0}
.reference-note strong{font-weight:500;color:#15394e}
.reference-legend{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:24px;margin:30px 0}
.reference-legend>div{border-top:2px solid #8eafc3;padding-top:18px}
.reference-legend dt{font-size:1.125rem;font-weight:500;margin-bottom:8px}
.reference-legend dd{font-size:1rem;line-height:1.75;color:#385366;margin:0}
.reference-table-block{margin:30px 0 36px;min-width:0}
.reference-table-block:focus-visible,.genomics-reference :focus-visible{outline:3px solid #326e96;outline-offset:4px}
.reference-table{width:100%;border-collapse:collapse;table-layout:fixed;font-size:1rem;line-height:1.65}
.reference-table caption{text-align:left;font-size:1.25rem;font-weight:450;color:#183c52;padding:0 0 14px}
.reference-table caption span{display:block;font-size:1rem;font-weight:400;color:#3d5a6b;padding-top:4px}
.reference-table thead{background:#15394e;color:#f5f9fc}
.reference-table th,.reference-table td{text-align:left;vertical-align:top;padding:16px 18px;border-bottom:1px solid #c7d8e2;overflow-wrap:anywhere}
.reference-table th{font-weight:500}
.reference-table td{color:#2c4a5f}
.reference-table tbody tr:nth-child(odd){background:#eaf1f5}
.reference-table tbody tr:nth-child(even){background:#f7fafb}
.reference-table tbody th{color:#193e55}
.reference-table td a{white-space:nowrap}
.reference-table .technical-value{font-family:var(--mono);font-size:1rem;word-break:break-word}
.reference-table .variant-list{display:flex;flex-wrap:wrap;gap:5px 13px}
.reference-table .variant-list span{overflow-wrap:anywhere}
.reference-table [hidden],.reference-empty[hidden]{display:none!important}
.reference-empty{font-size:1.0625rem;line-height:1.7;padding:22px;background:#e3edf3;border:1px solid #b2c9d8}
.reference-empty button{margin:12px 0 0}
.reference-filter{display:flex;flex-wrap:wrap;align-items:center;gap:12px;margin:24px 0 12px}
.reference-filter label{font-size:1rem;font-weight:450}
.reference-filter select{font:inherit;font-size:1rem;max-width:100%;min-height:46px;border:1px solid #849faf;background:white;color:#15394e;padding:9px 36px 9px 12px;border-radius:3px}
.reference-table-hereditary th:nth-child(1){width:13%}.reference-table-hereditary th:nth-child(2){width:23%}.reference-table-hereditary th:nth-child(3){width:43%}.reference-table-hereditary th:nth-child(4){width:21%}
.reference-table-pgx th:nth-child(1){width:15%}.reference-table-pgx th:nth-child(2){width:25%}.reference-table-pgx th:nth-child(3){width:60%}
.reference-table-medications th:nth-child(1){width:30%}.reference-table-medications th:nth-child(2){width:70%}
.reference-table-variants th:nth-child(1){width:24%}.reference-table-variants th:nth-child(2){width:21%}.reference-table-variants th:nth-child(3){width:14%}.reference-table-variants th:nth-child(4){width:17%}.reference-table-variants th:nth-child(5){width:24%}
.reference-review-grid{display:grid;grid-template-columns:1fr 1fr;gap:26px 40px;margin-top:30px}
.reference-review-grid>div{border-top:1px solid #a9c1d0;padding-top:6px}
.reference-review-grid h3{margin-top:18px}
.reference-review-grid p{font-size:1.125rem;line-height:1.8;color:#304b5b}
.reference-sources{display:grid;grid-template-columns:1fr 1fr;gap:18px 40px;list-style:none;padding:0!important}
.reference-sources li{font-size:1rem;line-height:1.7}
.reference-back-top{position:fixed;bottom:22px;right:22px;z-index:40;display:flex;align-items:center;justify-content:center;width:48px;height:48px;background:#163c54;color:#fff;border:1px solid #b6d0e0;border-radius:50%;text-decoration:none;box-shadow:0 3px 12px #142a3a20;font-size:1.5rem}
.reference-back-top[hidden]{display:none}
@media(max-width:1050px){.reference-nav-links{gap:0}.reference-nav-links a{font-size:1rem;padding:14px 8px}.reference-table th,.reference-table td{padding:14px 12px}}
@media(max-width:750px){.reference-hero{padding:22px 0 32px}.reference-hero h1{font-size:clamp(2.2rem,8vw,3.3rem)}.reference-hero .detail-breadcrumbs{margin-bottom:26px}.reference-intro{font-size:1.125rem}.reference-meta{gap:10px;font-size:1rem;display:block}.reference-meta span{display:block;margin:8px 0}.reference-meta span+span{padding:0;border:0}.reference-nav-links{display:none}.reference-nav-mobile{display:grid;grid-template-columns:auto minmax(0,1fr);align-items:center;gap:10px}.reference-nav-mobile label{max-width:86px;line-height:1.3}.reference-body{padding-top:28px}.reference-search{padding:22px 18px;margin-bottom:28px}.reference-search-controls{flex-wrap:wrap}.reference-search input{flex-basis:100%;width:100%}.reference-search button{padding:10px 18px}.reference-section{margin-bottom:32px;padding-bottom:32px}.reference-section h2{font-size:1.9rem}.reference-legend,.reference-review-grid,.reference-sources{grid-template-columns:1fr;gap:20px}.reference-note{padding:20px}.reference-table{display:block;font-size:1rem}.reference-table caption{display:block}.reference-table thead{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}.reference-table tbody{display:block}.reference-table tbody tr{display:block;border:1px solid #b7cedc;margin-bottom:14px;border-radius:4px;padding:6px 0}.reference-table tbody th,.reference-table tbody td{display:block!important;width:auto!important;border:0;padding:8px 16px}.reference-table tbody td::before{content:attr(data-label);display:block;color:#375d73;font-weight:500;font-size:1rem;margin-bottom:3px}.reference-table tbody th{font-size:1.125rem;border-bottom:1px solid #c5d6e0;padding:12px 16px;margin-bottom:5px}.reference-table .technical-value{font-size:1rem}.reference-filter{display:block}.reference-filter label{display:block;margin-bottom:8px}.reference-filter select{width:100%}.reference-back-top{bottom:16px;right:14px;width:46px;height:46px}.reference-scope{font-size:1.0625rem}.reference-table-block{margin-bottom:28px}}
@media print{.reference-nav,.reference-search,.reference-filter,.reference-back-top,.reference-empty{display:none}.reference-table [hidden]{display:table-row!important}.reference-table thead{display:table-header-group}.reference-table tr{break-inside:avoid}.reference-section{scroll-margin-top:0}.reference-hero{padding-bottom:20px}.reference-table th,.reference-table td{font-size:9pt;padding:5px}.reference-review-grid{display:block}}

.genomics-reference .site-header{z-index:50}
.reference-table-block,.reference-search{scroll-margin-top:calc(var(--reference-nav-height,70px) - 4px)}
@media(max-width:750px){.reference-results{padding:22px 18px;margin-top:-8px;margin-bottom:32px}.reference-results-heading h2{font-size:1.5rem}.reference-result-list{grid-template-columns:1fr}.reference-result-link{padding:16px}.reference-result-group h3{font-size:1rem}}
@media print{.reference-results,.reference-results-return{display:none!important}.reference-table tbody tr.reference-target{outline:0}.reference-table tbody tr.reference-target>*{background:transparent}}